Clinico- Histomorphological Variations in
Somil Singhal1*, Arun. T. Miskin2, V D Dombale3, Smita Kadadavar4
1Post Graduate, Department of Pathology, SN Medical College, Karnataka, India
2Associate Professor, Department of Pathology, SN Medical College, Karnataka, India
3Professor and HOD, Department of Pathology, SN Medical College, Karnataka, India
4Assistant Professor, Department of Pathology, SN Medical College, Karnataka, India
*Address for Correspondence: Dr. Somil Singhal, Post Graduate, Department of Pathology, S. Nijalingappa Medical
College and HSK Hospital, Bagalkot, Karnataka, India
ABSTRACT- Introduction- Fibroadenomas are the most common benign breast tumors, which typically present as a
mobile palpable breast lump. It accounts for approximately 75% of all breast lesions in young females. It can undergo a
variety of histological variations, Like Apocrine metaplasia, adenosis, leaf like pattern, stromal growth and myxoid
change. Therefore, this study was done to evaluate the clinico- histomorphological variations in fibroadenoma.
Materials and Methods- A retrospective study was done over a one year period from January 2015 to December 2015 at
S. Nijalingappa Medical College and HSK Hospital, Bagalkot, Karnataka, India. All cases of breast lump confirmed as a
fibroadenoma on histopathology were included in this study. A total of 224 cases were analyzed.
Results- The most common affected age group in the present study was 21- 30 years of age (50.45%). The majority of
them presented as a unilateral lump (56.70%) and very few bilateral (4.02%). The size varies between 3-5 cms and
commonly located in upper lateral quadrant (54.91%). The predominant growth pattern noted is mixed intracanalicular
and pericanalicular (55.35%). The common histological changes noted were stromal overgrowth (12.05%) followed by
apocrine metaplasia (9.37%) and cystic dilatation (8.92%). Rare variations such as lactational change (1.33%) and
infarction (1.78%) are also noted.
Conclusion- There is numerous clinico-histomorphological variations in fibroadenoma which can be confused with other
benign breast diseases. Therefore, a thorough knowledge of these changes is necessary for accurate diagnosis of
Key-words- Benign Breast Diseases (BBDs), Fibroadenoma, Histomorphological variants, Breast tumors