http://dx.doi.org/10.21276/ijlssr.2017.3.2.6

A Study on Formulation of Multiparticulate Gastro Retentive Drug Delivery System of Curcumin

Abhishek Kumar1*, Brijesh Kr. Tiwari2, Ravi Kant3

1Research Scholar, Department of Pharmacy, Mewar University (Rajasthan), India

2Research Supervisor, Department of Pharmacy, Mewar University (Rajasthan), India

3Director (Applied Research), Department of Pharmacy, Mewar University (Rajasthan), India

*Address for Correspondence: Mr. Abhishek Kumar, Research Scholar, Department of Pharmacy, Mewar University

(Rajasthan), India

ABSTRACT- The objective of our present study was to develop multiparticulate gastro retentive drug delivery system of Curcumin. The gastro retentive drug delivery system can be formulated to improve the absorption and bio-availability of curcumin by retaining the system into the stomach for prolonged period of time. The floating drug delivery system of curcumin was prepared by emulsion solvent diffusion method by using ethyl cellulose, Eudragit L100, HPMC, Phyllium husk polymers in varying concentration. Formulations were evaluated for percent yield, particle size, entrapment efficiency, in vitro buoyancy as well as in vitro release studies. The optimized formulations show good buoyancy and in vitro controlled release of Curcumin.

Key-words- Floating microsphere, Ethyl cellulose, Hydroxypropyl Methyl cellulose (HPMC), Eudragit L 100, Phyllium Husk

http://dx.doi.org/10.21276/ijlssr.2017.3.2.13

Studies on Traditional Knowledge of Medicinal

Flora and its Contribution to Livelihood

Enhancement in the Doon-Valley, Uttrakhand

(India)

Ankush Sharma, Harmanjeet Singh, Narendra Kumar*

1PG Scholar-Uttaranchal College of Sciences and Technology, Dehradun, UK, India

2Head, Department of Botany, Alpine Institute of Management and Technology, Dehradun, UK, India

*Address for Correspondence: Dr. Narendra Kumar, Head, Department of Botany, Alpine Institute of Management and

Technology, Dehradun, UK, India

ABSTRACT- Uttrakhand has tremendous potential for medicinal plants cultivation and in becoming one of the  important options for sustainable livelihood in the Doon valley as well as all hilly regions. Doon-valley, Uttrakhand can take advantages of increasing demand and low availability of medicinal and aromatic plants resources in the other part of the country and start to grow highly valuable medicinal plants in high altitude areas. Medicinal and aromatic plants can play an important role in the subsistence livelihood enhancement rural people, especially women through an environmentally sustainable manner while maintaining the biodiversity of these natural products.

Key-words- Endangered plants, Medicinal flora, Indigenous use, Medicinal and aromatic plants

http://dx.doi.org/10.21276/ijlssr.2017.3.2.11

Emerging Trends to Minimize the Post Harvest

Decay of Perishable Fruits

Geetanjli*

Department of Botany, Dev Samaj College for Women, Ferozepur, Punjab, India

*Address for Correspondence: Dr. Geetanjli, Asst. Professor, Department of Botany, Dev Samaj College, Ferozepur,

Punjab, India

ABSTRACT- Fruits and vegetables are mainly consumed for their nutritive value. India ranks high in the world in

production of these commodities. But, a major part of the yield is lost due to a number of factors. Post harvest decay due

to attack by a variety of pathogen is one of the main reason responsible for such losses. Most of the fruits and vegetable

are prone to attack by post harvest pathogens. But, perishable fruits are at maximum risk due high moisture content

present in them. Various control measures have been practiced against the fungal pathogens. Tradionally used methods

like irradiation, use of chemical fungicides etc. have certain environmental and health hazards associated with them.

Recent trends are shifting towards safe and consumer friendly strategies to control the post harvest decay of perishable

fruits. Presently, trends are focusing on enhancement of the shelf life of perishables along with the minimization of the

losses in quantitative as well as qualitative terms. In the recent past, a metamorphic change in the post harvest

management scenario has been observed. Emerging trends are aimed at use of biological control measures to combat the

post harvest losses.

Key-words- Post harvest decay, Perishables, Fungal pathogens, Biological control, Post harvest management, Emerging

trends, Consumer friendly strategies

http://dx.doi.org/10.21276/ijlssr.2017.3.2.1

Role of Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus and Pre-diabetes

Naresh Kumar Jha*

Department of Biochemistry, Lord Buddha Koshi Medical College, Saharsa, Bihar, India

*Address for Correspondence: Dr. Naresh Kumar Jha, Associate Professor, Department of Biochemistry,

Lord Buddha Koshi Medical College, Saharsa, Bihar, India

ABSTRACT- Introduction: Importance of measurement of glycated hemoglobin (HbA1c) has been recommended for

the diagnosis of diabetes and pre-diabetes. However, various epidemiological studies conducted different parts of the

universe have shown significant discordance between HbA1c and glucose-based tests. Glycated hemoglobin (HbA1c) is

assumed to be the gold standard for monitoring glycemic control in patients with diabetes mellitus disorder. The Glycated

hemoglobin (HbA1c) assay provided an accurate, precise measure of chronic glycemic levels, and associates with the risk

of diabetes complications.

Materials and Methods: This is a cross sectional prospective study. A total of 868 individuals attended to the medicine

outpatient clinic at Lord Buddha Koshi Medical College, Saharsa, Bihar between Jan 2016 to Dec 2016 were selected for

the study after screening a large cohort visited OPD. The results of FPG, OGTT, and HbA1c for 868 individual were

analyzed as well as all grouped as diabetic patients, glucose intolerant (pre-diabetes) patients, and non-diabetic patients

according to new ADA criteria for the diagnosis of diabetes.

Results: Diagnostic sensitivity of all diabetic criteria were 80.33% for A1c; 75% for OGTT and only 41.87% for FPG

respectively.

Conclusion: The proposed A1c diagnostic criteria have greater diagnostic than FPG and 2-h OGTT regarding a diagnosis

of diabetes mellitus disorder.

Key-words- Glycated Hemoglobin, Fasting Plasma Glucose, Oral glucose tolerances test (OGTT), Diabetes Mellitus,

and Pre- diabetes

http://dx.doi.org/10.21276/ijlssr.2017.3.2.7

Anti-inflammatory Activity of Sting Protein from Apis mellifera

Sumesh Shah1, Amit Gupta2, 3*, Shweta P Karne1, Sanjay Kamble1, Bharat Shinde1,2, 3

1Department of Microbiology, Vidya Pratishthan’s, Arts, Science and Commerce College, Baramati, Maharashtra, India

2Department of Zoology, Vidya Pratishthan’s, Arts, Science and Commerce College, Baramati, Maharashtra, India

3Department of Immunology and Virology, Vidya Pratishthan’s School of Biotechnology (VSBT, Research Centre

affiliated to Savitribai Phule Pune University), Baramati, Maharashtra, India

*Address for Correspondence: Dr. Amit Gupta, Assistant Professor/Senior Scientist, Department of Biotechnology,

Vidya Pratishthan’s, Arts, Science and Commerce College, Baramati, Maharashtra, India

ABSTRACT- The objective of our study is to determine its anti-inflammatory potential of protein extracted from the

stings of honey bee (Apis mellifera). In this study, protein extracted from the stings of Apis mellifera using Tris HCl/ice

cold acetone and determined through Nano drop method and then determined its Da protein using SDS-PAGE. In

addition, indirect ELISA was performed using rubella vaccine as coating antigen and determined its antibody titre using

variable concentration of sting protein (15.62-250 μg) and also determined its activity on human whole blood for

determining total cellular content and proliferation against rubella vaccine antigen. The results showed that protein from

stings of Apis mellifera showed drastic declined in antibody titre at higher doses but there is slightly enhancement in

antibody titre, total cellular content and proliferations at lower concentration as compared to control and rubella vaccine

(standard).Overall, this study suggest that stings protein of Apis mellifera showed anti-inflammatory potential against

rubella vaccine antigen.

Key-words- Anti-inflammatory, Apis mellifera, Stings, Nanodrop, ELISA

http://dx.doi.org/10.21276/ijlssr.2017.3.2.8

Clinico- Histomorphological Variations in

Fibroadenoma

Somil Singhal1*, Arun. T. Miskin2, V D Dombale3, Smita Kadadavar4

1Post Graduate, Department of Pathology, SN Medical College, Karnataka, India

2Associate Professor, Department of Pathology, SN Medical College, Karnataka, India

3Professor and HOD, Department of Pathology, SN Medical College, Karnataka, India

4Assistant Professor, Department of Pathology, SN Medical College, Karnataka, India

*Address for Correspondence: Dr. Somil Singhal, Post Graduate, Department of Pathology, S. Nijalingappa Medical

College and HSK Hospital, Bagalkot, Karnataka, India

ABSTRACT- Introduction- Fibroadenomas are the most common benign breast tumors, which typically present as a

mobile palpable breast lump. It accounts for approximately 75% of all breast lesions in young females. It can undergo a

variety of histological variations, Like Apocrine metaplasia, adenosis, leaf like pattern, stromal growth and myxoid

change. Therefore, this study was done to evaluate the clinico- histomorphological variations in fibroadenoma.

Materials and Methods- A retrospective study was done over a one year period from January 2015 to December 2015 at

S. Nijalingappa Medical College and HSK Hospital, Bagalkot, Karnataka, India. All cases of breast lump confirmed as a

fibroadenoma on histopathology were included in this study. A total of 224 cases were analyzed.

Results- The most common affected age group in the present study was 21- 30 years of age (50.45%). The majority of

them presented as a unilateral lump (56.70%) and very few bilateral (4.02%). The size varies between 3-5 cms and

commonly located in upper lateral quadrant (54.91%). The predominant growth pattern noted is mixed intracanalicular

and pericanalicular (55.35%). The common histological changes noted were stromal overgrowth (12.05%) followed by

apocrine metaplasia (9.37%) and cystic dilatation (8.92%). Rare variations such as lactational change (1.33%) and

infarction (1.78%) are also noted.

Conclusion- There is numerous clinico-histomorphological variations in fibroadenoma which can be confused with other

benign breast diseases. Therefore, a thorough knowledge of these changes is necessary for accurate diagnosis of

fibroadenoma.

Key-words- Benign Breast Diseases (BBDs), Fibroadenoma, Histomorphological variants, Breast tumors

http://dx.doi.org/10.21276/ijlssr.2017.3.2.10

Age Specific Prevalence of Low Back Pain:

A Hospital Based Cross-sectional Study

Amaresh Prasad Sinha*

Assoc. Prof., Department of Orthopedic, Lord Buddha Koshi Medical College, Saharsa, Bihar, India

*Address for Correspondence: Dr. Amaresh Prasad Sinha, Associate Professor, Department of Orthopedic,

Lord Buddha Koshi Medical College, Saharsa, Bihar, India

ABSTRACT- Introduction: Low back pain (LBP) is an important clinical, social, economic, and public health problem

affecting the population indiscriminately. It is a disorder with many possible etiologies, occurring in many groups of the

population, and with many definitions. Nearly everyone will experience some form of back pain in his or her lifetime.

Materials ans& Methods: The current study is a cross sectional study undertaken at Lord Buddha Koshi Medical

College, Saharsa, Bihar, India from Aug 2015 to Dec 2015. The objective of this study was to see the age specific

prevalence of low back pain among 400 subjects visiting the Orthopedics OPD of the hospital. The age range of the study

participants were 25 years to 65 years. The national guidelines of LBP diagnosis is used as diagnostic criteria.

Results: Overall prevalence of LBP was found as 31.25%. The highest prevalence was seen in 55-65 years age group.

Age had positive association & important risk factors of increasing burden of LBP.

Conclusion: LBP is an important health problem & affecting all age groups and it is responsible for a great economic loss

of any country.

Key-words- Low Back Pain, Prevalence, Public Health