http://dx.doi.org/10.21276/ijlssr.2017.3.2.1

Role of Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus and Pre-diabetes

Naresh Kumar Jha*

Department of Biochemistry, Lord Buddha Koshi Medical College, Saharsa, Bihar, India

*Address for Correspondence: Dr. Naresh Kumar Jha, Associate Professor, Department of Biochemistry,

Lord Buddha Koshi Medical College, Saharsa, Bihar, India

ABSTRACT- Introduction: Importance of measurement of glycated hemoglobin (HbA1c) has been recommended for

the diagnosis of diabetes and pre-diabetes. However, various epidemiological studies conducted different parts of the

universe have shown significant discordance between HbA1c and glucose-based tests. Glycated hemoglobin (HbA1c) is

assumed to be the gold standard for monitoring glycemic control in patients with diabetes mellitus disorder. The Glycated

hemoglobin (HbA1c) assay provided an accurate, precise measure of chronic glycemic levels, and associates with the risk

of diabetes complications.

Materials and Methods: This is a cross sectional prospective study. A total of 868 individuals attended to the medicine

outpatient clinic at Lord Buddha Koshi Medical College, Saharsa, Bihar between Jan 2016 to Dec 2016 were selected for

the study after screening a large cohort visited OPD. The results of FPG, OGTT, and HbA1c for 868 individual were

analyzed as well as all grouped as diabetic patients, glucose intolerant (pre-diabetes) patients, and non-diabetic patients

according to new ADA criteria for the diagnosis of diabetes.

Results: Diagnostic sensitivity of all diabetic criteria were 80.33% for A1c; 75% for OGTT and only 41.87% for FPG

respectively.

Conclusion: The proposed A1c diagnostic criteria have greater diagnostic than FPG and 2-h OGTT regarding a diagnosis

of diabetes mellitus disorder.

Key-words- Glycated Hemoglobin, Fasting Plasma Glucose, Oral glucose tolerances test (OGTT), Diabetes Mellitus,

and Pre- diabetes