http://dx.doi.org/10.21276/ijlssr.2017.3.2.6

A Study on Formulation of Multiparticulate Gastro Retentive Drug Delivery System of Curcumin

Abhishek Kumar1*, Brijesh Kr. Tiwari2, Ravi Kant3

1Research Scholar, Department of Pharmacy, Mewar University (Rajasthan), India

2Research Supervisor, Department of Pharmacy, Mewar University (Rajasthan), India

3Director (Applied Research), Department of Pharmacy, Mewar University (Rajasthan), India

*Address for Correspondence: Mr. Abhishek Kumar, Research Scholar, Department of Pharmacy, Mewar University

(Rajasthan), India

ABSTRACT- The objective of our present study was to develop multiparticulate gastro retentive drug delivery system of Curcumin. The gastro retentive drug delivery system can be formulated to improve the absorption and bio-availability of curcumin by retaining the system into the stomach for prolonged period of time. The floating drug delivery system of curcumin was prepared by emulsion solvent diffusion method by using ethyl cellulose, Eudragit L100, HPMC, Phyllium husk polymers in varying concentration. Formulations were evaluated for percent yield, particle size, entrapment efficiency, in vitro buoyancy as well as in vitro release studies. The optimized formulations show good buoyancy and in vitro controlled release of Curcumin.

Key-words- Floating microsphere, Ethyl cellulose, Hydroxypropyl Methyl cellulose (HPMC), Eudragit L 100, Phyllium Husk